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Comparative Genomic Hybridization

Comparative Genomic Hybridization

Comparative Genomic Hybridization (CGH) is the preferred method for genome-wide analysis of DNA[1] that identifies small deletion and/or duplications in chromosomal regions. By having a labeled DNA of interest hybridize with a labelled normal DNA, CGH generates a map of DNA with copy number changes[2].

CGH has advanced in becoming essential in analyzing chromosomal imbalances. However, the sensitivity of CGH can be thwarted by contaminants[3] yielding false positives that can considerably slow down the process. Therefore, MBI products are assayed for contaminating endonuclease and optimized for all critical assays requiring the highest degree of specificity and purity.

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